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Profhilo: The Injectable Skin Booster That Starts Working From the First Treatment

Dennis Keller by Dennis Keller
July 9, 2025
in Lifestyle
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Preventative Botox®: The Strategy for Keeping Skin Smooth Before Wrinkles Set In

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Most people want healthy-looking skin. Profhilo steps into that conversation with a very different approach compared to traditional dermal fillers.

Instead of adding volume or reshaping features, Profhilo works on skin quality itself. It’s not about plumping one area. It’s about treating the whole face, or other parts of the body, to bring back elasticity, hydration, and tone. What makes it stand out is its formula—pure hyaluronic acid in a high concentration. That’s the only ingredient. No additives. No BDDE like you find in traditional fillers.

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What Makes Profhilo Different?

Profhilo doesn’t behave like typical hyaluronic acid fillers. It doesn’t stay in one spot or create structure. Once injected, it spreads out beneath the skin’s surface and stimulates collagen and elastin production. Think of it like a skin booster, not a sculpting tool.

Because it spreads evenly across facial areas, profhilo treatments work especially well for improving overall texture and hydration. That makes it ideal for treating skin ageing in early stages—fine lines, dull tone, and skin laxity.

How the Procedure Works

Profhilo injections go into specific areas using a set of injection sites. These sites are chosen for safety and results. The product is injected just under the skin using a very fine needle. Patients might feel a small pinch at each point, but the process is quick. Most appointments last less than 30 minutes.

There are usually two treatments. The first profhilo treatment starts the process. The second session comes four weeks later. Together, they trigger intense hydration and long-term collagen production. Some people opt for a top up every 6–9 months to maintain results.

What Happens After Injection?

Most people return to work right after treatment. Some might see minor bruising or swelling at the injection site. That fades in a few days. It’s smart to follow aftercare instructions closely. Avoid alcohol, sun exposure, and strenuous exercise for 24 hours after being treated.

Even though profhilo is a naturally occurring substance, it’s still a medical procedure. Qualified practitioners screen each patient for risks. Those with a history of reactions or certain medical conditions may not be ideal candidates. A full review of your medical history is always done beforehand.

Profhilo and Skin Health

Results build slowly. You won’t walk out looking instantly different. But by week four, most people notice better skin tone, fewer fine lines, and a firmer look overall. That’s because the treatment doesn’t add volume—it improves skin structure by activating the body’s own repair systems.

Collagen and elastin are proteins your body stops producing at full speed after age 25. Profhilo wakes them up again. Unlike traditional fillers that fill hollows, profhilo asks your body to rebuild.

That’s why skin boosters like profhilo are popular in cosmetic dermatology and aesthetic medicine. They give you more natural results without changing your features.

Who Profhilo Works Best For

People in their 30s and 40s often see early signs of skin ageing—lines around the mouth, loss of firmness, or dull skin. Profhilo works best before deep wrinkles set in. It suits people looking for an overall lift and glow, rather than sculpted cheekbones or volume.

It’s also a strong option for those who aren’t ready for traditional fillers. There’s less risk of lumpiness or distortion. The product blends into the tissue evenly, thanks to its high molecular weight and unique formulation.

Treated areas usually include the face, neck, or even hands. Anywhere skin hydration and texture need help. It works best when collagen is still active but dropping. For those with very loose or sagging skin, a reconstructive surgeon might suggest other injectable treatments instead.

Safety, Side Effects, and Recovery

Like any injectable treatment, profhilo injections have some possible side effects. Minor bruising, swelling, or tenderness around the treated area are common. Rare complications include blood vessel blockage or tissue damage, though that’s very unlikely when using an experienced practitioner.

Choosing the right treatment depends on your goals and your skin. Some patients want to correct volume loss with dermal fillers. Others care more about tone and texture, which is where profhilo shines.

Results usually peak after two treatments, then slowly fade over 6–9 months. If you keep up with top up sessions, the skin stays hydrated and firmer long-term.

What to Expect from a Qualified Practitioner

An experienced practitioner won’t treat every face the same way. They assess your facial areas, talk through your goals, and plan the injection sites with care. They’ll also give you aftercare instructions and tell you what to expect based on your age, skin quality, and previous treatments.

Profhilo is different from most injectable treatments. It doesn’t add volume. It rebuilds structure. And it does that by giving your body what it used to produce on its own—collagen, elastin, and moisture.

If you want smoother texture, better skin tone, and a natural glow, profhilo may be the right treatment. Profhilo works best when used early, before deep wrinkles and sagging take hold.

The Takeaway

The skin doesn’t bounce back like it used to, but that doesn’t mean your only option is to add volume. Profhilo gives your skin a chance to repair from within, starting with the first treatment and building toward visible change after the second treatment. It’s a subtle way to get youthful skin without disrupting small blood vessels or overworking the face.

Frequently Asked Questions

What happens during the first treatment with Profhilo?

The first treatment introduces hyaluronic acid beneath the skin to kickstart hydration and collagen support.

Why is the second treatment necessary?

The second treatment reinforces the effects of the first and helps maintain youthful skin over time.

Can Profhilo damage small blood vessels?

When injected correctly, Profhilo avoids small blood vessels and spreads safely in the tissue.

How long between the first and second treatment?

There are usually four weeks between the first and second treatment for best results.

Dennis Keller

Dennis Keller

Lifestyle Editor

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